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Enhancing thermostability of -mannanase by protective additives

LIU Zhaohui, QI Wei, WU Weina, LIU Yue, HE Zhimin

Frontiers of Chemical Science and Engineering 2008, Volume 2, Issue 4,   Pages 439-442 doi: 10.1007/s11705-008-0062-8

Abstract: sugars (glucose, mannose, fructose, sucrose and chitosan) and polyols (glycol, glycerol and sorbitol) as protectiveadditive on the thermostability of -mannanase were studied.The optimal combination additive proportion was sucrose: chitosan : sorbitol = 1 : 2 : 2 (molar ratioThe sucrose, chitosan, glycerol, sorbitol and the combination additive might increase the optimal reactionMeanwhile, the protective mechanism of the additives against deactivation of enzyme was also discussed

Keywords： protective additive     g/L     orthogonal experimental     combination additive     corresponding    

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The influence of brain death on donor liver and the potential mechanisms of protective intervention

Shui-Jun ZHANG, Tao WANG

Frontiers of Medicine 2011, Volume 5, Issue 1,   Pages 8-14 doi: 10.1007/s11684-011-0109-y

Abstract: influence of brain death on the viability of donor livers and to summarize the mechanisms of the different protective

Keywords： brain death     donor liver    

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Additive Design and Manufacturing of Jet Engine Parts

Pinlian Han

Engineering 2017, Volume 3, Issue 5,   Pages 648-652 doi: 10.1016/J.ENG.2017.05.017

Abstract:

The additive design (AD) and additive manufacturing (AM) of jet engine parts will revolutionize the

Keywords： Additive manufacturing     Additive design     Jet engine     Porous structure    

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PAK1 is a novel cardiac protective signaling molecule

Yunbo Ke,Xin Wang,Xu Yu Jin,R. John Solaro,Ming Lei

Frontiers of Medicine 2014, Volume 8, Issue 4,   Pages 399-403 doi: 10.1007/s11684-014-0380-9

Abstract:

We review here the novel cardiac protective effects of the multifunctional enzyme, p21-activated kinaseassemble an overview of the recent findings on PAK1 signaling in the heart, particularly its cardiac protectiveWe discuss the anti-adrenergic and antihypertrophic cardiac protective effects of PAK1, as well as its

Keywords： p21-activated kinase 1 (PAK1)     heart    

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Antioxidative potential of metformin: Possible protective mechanism against generating OH radicals

Huibin Guo, Ning Wang, Xiang Li

Frontiers of Environmental Science & Engineering 2021, Volume 15, Issue 2, doi: 10.1007/s11783-020-1313-2

Abstract: Abstract • Metformin consumes O2−• and OH• induced by PM are proposed. • OH• dominated the oxidation of metformin compared with O2−• • Metformin can prevent the harm of ROS induced by PM to human health. • Antioxidative potential of metformin was first proposed to provide measures. Exposure to particulate matter (PM) can lead to the excessive accumulation of reactive oxygen species (ROS), which causes oxidative stress and endangers human health. In this study, the effects of metformin on PM-induced radicals were investigated, and the antioxidation reaction mechanism of metformin was analyzed by the density functional theory (DFT) method. The corresponding results revealed that the consumption rate of dithiothreitol (DTT) increased as the metformin concentration (0–40 mmol/L) increased under exposure to PM active components. Moreover, the OH radical content decreased as the metformin concentration increased. This result may be related to the consumption of PM-induced OH radicals by metformin, which promotes the DTT consumption rate. Additionally, because the initiation reaction has a high barrier, the oxidation reaction rate between metformin and •O2− is not very fast, although various catalysts may be present in the human environment. Importantly, we found that the barrier of metformin induced by OH radicals is only 9.6 kcal/mol while the barrier of metformin induced by oxygen is 57.9 kcal/mol, which shows that the rate of the •OH-initiated oxidative reaction of metformin is much faster and that this reaction path occurs more easily. By sample analysis, the mean OH radical generation was 55 nmol/min/g (ranging from 5 to 105 nmol/min/g) on haze days and 30 nmol/min/g (ranging from 10 to 50 nmol/min/g) on non-haze days. Moreover, OH radical generation was higher on haze days than on neighboring non-haze days. Taken together, all data suggest that metformin could consume the PM-induced radicals, such as OH radicals and •O2−, thereby providing health protection.

Keywords： Antioxidative potential     Metformin     Mechanism     OH radical     Health protection.    

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Nano-copper ions assembled cellulose-based composite with antibacterial activity for biodegradable personal protective

Frontiers of Chemical Science and Engineering 2023, Volume 17, Issue 10,   Pages 1544-1554 doi: 10.1007/s11705-022-2288-2

Abstract: The current SARS-CoV-2 pandemic has resulted in the widespread use of personal protective equipment,transmission, resource consumption, and environmental impact of waste, while also expanding the range of protective

Keywords： cellulose-based     nanocomposite     biodegradable antibacterial fabric     nano-copper ions     face masks    

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Compressive behavior and energy absorption of polymeric lattice structures made by additive manufacturing

Sheng WANG, Jun WANG, Yingjie XU, Weihong ZHANG, Jihong ZHU

Frontiers of Mechanical Engineering 2020, Volume 15, Issue 2,   Pages 319-327 doi: 10.1007/s11465-019-0549-7

Abstract: Lattice structures have numerous outstanding characteristics, such as light weight, high strength, excellent shock resistance, and highly efficient heat dissipation. In this work, by combining experimental and numerical methods, we investigate the compressive behavior and energy absorption of lattices made through the stereolithography apparatus process. Four types of lattice structures are considered: (i) Uniform body-centered-cubic (U-BCC); (ii) graded body-centered-cubic (G-BCC); (iii) uniform body-centered-cubic with -axis reinforcement (U-BCCz); and (iv) graded body-centered-cubic with -axis reinforcement (G-BCCz). We conduct compressive tests on these four lattices and numerically simulate the compression process through the finite element method. Analysis results show that BCCz has higher modulus and strength than BCC. In addition, uniform lattices show better energy absorption capabilities at small compression distances, while graded lattices absorb more energy at large compression distances. The good correlation between the simulation results and the experimental phenomena demonstrates the validity and accuracy of the present investigation method.

Keywords： lattice structure     polymer     compressive behavior     additive manufacturing     simulation    

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Effect of hyperlipidemia on endothelial VCAM-1 expression and the protective role of fenofibrate

WU Jun, LIN Jinchao, HE Zhaochu, OU Biru, GUO Haisen

Frontiers of Medicine 2007, Volume 1, Issue 4,   Pages 356-358 doi: 10.1007/s11684-007-0068-5

Abstract: The effect of hyperlipidemia and inflammation on endothelial functions was studied. The enrolled included control (basic chow), hyperlipidemia and fenofibrate-treated groups (high fat diet). The hyperlipidemia model was set up by four-week atherogenic diet, followed by a 16-week treatment in the fenofibrate-treated group (fenofibrate 40 mg/kg every day) and without treatment in the hyperlipidemia group, respectively. In the 20th week, serum lipid level and NO levels were measured, and the expression of vascular cell adhesion molecule-1 (VCAM-1) and cell adhesiveness in aortic endothelia observed by computer-aided system. Compared with the control group, hyperlipidemia rats showed lower levels of NO and ncreases in leukocyte accumulation on the endothelial surface, also stronger and more extensive endothelial expression of VCAM-1. In fenofibrate-treated group, the expression of VCAM-1 and leukocyte accumulation on the endothelial surface was decreased, while serum levels of NO were increased as compared with hyperli pidemia group. Hyperlipidemia can inhibit the NO activity and promote the damage of VACA-1 to aortic endothelia. Fenofibrate can effectively prevent the pathogenesis of atherosclerosis by restoring NO levels and down-regulating the VCAM-1 expression.

Keywords： endothelial     16-week treatment     leukocyte accumulation     mg/kg     NO    

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Topology optimization based on reduction methods with applications to multiscale design and additive

Emmanuel TROMME, Atsushi KAWAMOTO, James K. GUEST

Frontiers of Mechanical Engineering 2020, Volume 15, Issue 1,   Pages 151-165 doi: 10.1007/s11465-019-0564-8

Abstract: Advanced manufacturing processes such as additive manufacturing offer now the capability to control materialmicro-structural periodicity are performed to illustrate the method, including applications to infill patterns in additive

Keywords： multiscale topology optimization     micro-structure     additive manufacturing     reduction techniques     substructuring    

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Immunogenicity and protective immunity against otitis media caused by pneumococcus in mice of Hib conjugate

Zeyu Chen,Rong Guo,Jianghong Xu,Chuangjun Qiu

Frontiers of Medicine 2016, Volume 10, Issue 4,   Pages 490-498 doi: 10.1007/s11684-016-0470-y

Abstract:

This study evaluated the immunogenicity and protective immunity of a Hemophilus influenzaeelimination rate of pneumococcus and the inflammation of the middle ear showed the effectiveness of protective

Keywords： conjugate vaccine     pneumococcal surface adhesin A     Hemophilus influenzae b     immunogenicity     otitis media    

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Surface accuracy optimization of mechanical parts with multiple circular holes for additive manufacturing

Jinghua XU, Hongsheng SHENG, Shuyou ZHANG, Jianrong TAN, Jinlian DENG

Frontiers of Mechanical Engineering 2021, Volume 16, Issue 1,   Pages 133-150 doi: 10.1007/s11465-020-0610-6

Abstract: Compared with traditional machining methods, additive manufacturing (AM) technology can decrease the

Keywords： surface accuracy optimization     multiple circular holes     additive manufacturing (AM)     part build orientation    

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Manufacturing cost constrained topology optimization for additive manufacturing

Jikai LIU, Qian CHEN, Xuan LIANG, Albert C. TO

Frontiers of Mechanical Engineering 2019, Volume 14, Issue 2,   Pages 213-221 doi: 10.1007/s11465-019-0536-z

Abstract: presents a manufacturing cost constrained topology optimization algorithm considering the laser powder bed additiveTopology optimization for additive manufacturing was recently extensively studied, and many related topicsHowever, metal additive manufacturing is an expensive process, and the high manufacturing cost severelyTechnically, the additive manufacturing cost model for laser powder bed-based process is establishedTherefore, by properly developing the sensitivity result, the metallic additive manufacturing part can

Keywords： topology optimization     manufacturing cost     additive manufacturing     powder bed    

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PROTECTIVE ROLES OF D1 PROTEIN TURNOVER AND THE XANTHOPHYLL CYCLE IN TOMATO (

Tao LU, Jiazhi LU, Mingfang QI, Zhouping SUN, Yufeng LIU, Tianlai LI

Frontiers of Agricultural Science and Engineering   Pages 262-279 doi: 10.15302/J-FASE-2021383

Abstract: D1 protein turnover and the xanthophyll cycle (XC) are important photoprotective mechanisms in plants that operate under adverse conditions. Here, streptomycin sulfate (SM) and dithiothreitol (DTT) were used in tomato plants as inhibitors of D1 protein turnover and XC to elucidate their photoprotective impacts under sub-high temperature and high light conditions (HH, 35°C, 1000 µmol·m ·s ). SM and DTT treatments significantly reduced the net photosynthetic rate, apparent quantum efficiency, maximum photochemical efficiency, and potential activity of photosystem II, leading to photoinhibition and a decline in plant biomass under HH. The increase in reactive oxygen species levels resulted in thylakoid membrane lipid peroxidation. In addition, there were increased non-photochemical quenching and decreased chlorophyll pigments in SM and DTT application, causing an inhibition of D1 protein production at both transcriptional and translational levels. Overall, inhibition of D1 turnover caused greater photoinhibition than XC inhibition. Additionally, the recovery levels of most photosynthesis indicators in DTT-treated plants were higher than in SM-treated plants. These findings support the view that D1 turnover has a more important role than XC in photoprotection in tomato under HH conditions.

Keywords： D1 turnover     photoinhibition     photoprotection     photosynthesis     tomato     xanthophyll cycle    

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Process development for green part printing using binder jetting additive manufacturing

Hadi MIYANAJI, Morgan ORTH, Junaid Muhammad AKBAR, Li YANG

Frontiers of Mechanical Engineering 2018, Volume 13, Issue 4,   Pages 504-512 doi: 10.1007/s11465-018-0508-8

Abstract:

Originally developed decades ago, the binder jetting additive manufacturing (BJ-AM) process possessesvarious advantages compared to other additive manufacturing (AM) technologies such as broad materialfabrication were discussed in detail in order to provide a comprehensive perspective of the design for additive

Keywords： binder jetting     additive manufacturing     green part     process optimization     process development    

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Glucagon-like peptide-2 exhibits protective effect on hepatic ischemia-reperfusion injury in rats

Naci Topaloğlu,Adem Küçük,Şule Yıldırım,Mustafa Tekin,Havva Erdem,Mustafa Deniz

Frontiers of Medicine 2015, Volume 9, Issue 3,   Pages 368-373 doi: 10.1007/s11684-015-0403-1

Abstract: However, its protective abilities against I/R injury in the liver are unknown.Our data suggested that GLP-2 pretreatment may have a protective effect on liver I/R injury.

Keywords： ischemia/reperfusion     liver     glucagon-like peptide-2     alanine aminotransferase    

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Title Author Date Type Operation

Enhancing thermostability of -mannanase by protective additives

LIU Zhaohui, QI Wei, WU Weina, LIU Yue, HE Zhimin

Journal Article

The influence of brain death on donor liver and the potential mechanisms of protective intervention

Shui-Jun ZHANG, Tao WANG

Journal Article

Additive Design and Manufacturing of Jet Engine Parts

Pinlian Han

Journal Article

PAK1 is a novel cardiac protective signaling molecule

Yunbo Ke,Xin Wang,Xu Yu Jin,R. John Solaro,Ming Lei

Journal Article

Antioxidative potential of metformin: Possible protective mechanism against generating OH radicals

Huibin Guo, Ning Wang, Xiang Li

Journal Article

Nano-copper ions assembled cellulose-based composite with antibacterial activity for biodegradable personal protective

Journal Article

Compressive behavior and energy absorption of polymeric lattice structures made by additive manufacturing

Sheng WANG, Jun WANG, Yingjie XU, Weihong ZHANG, Jihong ZHU

Journal Article

Effect of hyperlipidemia on endothelial VCAM-1 expression and the protective role of fenofibrate

WU Jun, LIN Jinchao, HE Zhaochu, OU Biru, GUO Haisen

Journal Article

Topology optimization based on reduction methods with applications to multiscale design and additive

Emmanuel TROMME, Atsushi KAWAMOTO, James K. GUEST

Journal Article

Immunogenicity and protective immunity against otitis media caused by pneumococcus in mice of Hib conjugate

Zeyu Chen,Rong Guo,Jianghong Xu,Chuangjun Qiu

Journal Article

Surface accuracy optimization of mechanical parts with multiple circular holes for additive manufacturing

Jinghua XU, Hongsheng SHENG, Shuyou ZHANG, Jianrong TAN, Jinlian DENG

Journal Article

Manufacturing cost constrained topology optimization for additive manufacturing

Jikai LIU, Qian CHEN, Xuan LIANG, Albert C. TO

Journal Article

PROTECTIVE ROLES OF D1 PROTEIN TURNOVER AND THE XANTHOPHYLL CYCLE IN TOMATO (

Tao LU, Jiazhi LU, Mingfang QI, Zhouping SUN, Yufeng LIU, Tianlai LI

Journal Article

Process development for green part printing using binder jetting additive manufacturing

Hadi MIYANAJI, Morgan ORTH, Junaid Muhammad AKBAR, Li YANG

Journal Article

Glucagon-like peptide-2 exhibits protective effect on hepatic ischemia-reperfusion injury in rats

Naci Topaloğlu,Adem Küçük,Şule Yıldırım,Mustafa Tekin,Havva Erdem,Mustafa Deniz

Journal Article